Send to

Choose Destination
Med Sci (Paris). 2019 Jun-Jul;35(6-7):527-534. doi: 10.1051/medsci/2019095. Epub 2019 Jul 5.

[Cytosolic DNA sensing by the cGAS-STING pathway in cancer].

[Article in French]

Author information

Centre de recherche en cancérologie de Lyon, UM5286 U1052, université de Lyon, centre Léon Bérard, 69008 Lyon, France.


Cyclic GMP-AMP synthase (cGAS) is a universal cytosolic DNA sensor that detects nucleic acids of pathogens. Upon DNA sensing, cGAS triggers the formation of the second intracellular messenger, the cyclic GMP-AMP (cGAMP), which activates the adaptor STING. STING engagement induces the secretion of cytokines and type I interferons that contribute to pathogen clearance. However, there is emerging evidence that cGAS is activated by self DNA in cancer cells and in antigen-presenting cells to trigger an antitumoral response. In this review, we will highlight the current understanding of self DNA sensing by cGAS in the context of cancer.


Supplemental Content

Full text links

Icon for EDP Sciences
Loading ...
Support Center