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Med Sci (Paris). 2019 Jun-Jul;35(6-7):527-534. doi: 10.1051/medsci/2019095. Epub 2019 Jul 5.

[Cytosolic DNA sensing by the cGAS-STING pathway in cancer].

[Article in French]

Author information

1
Centre de recherche en cancérologie de Lyon, UM5286 U1052, université de Lyon, centre Léon Bérard, 69008 Lyon, France.

Abstract

Cyclic GMP-AMP synthase (cGAS) is a universal cytosolic DNA sensor that detects nucleic acids of pathogens. Upon DNA sensing, cGAS triggers the formation of the second intracellular messenger, the cyclic GMP-AMP (cGAMP), which activates the adaptor STING. STING engagement induces the secretion of cytokines and type I interferons that contribute to pathogen clearance. However, there is emerging evidence that cGAS is activated by self DNA in cancer cells and in antigen-presenting cells to trigger an antitumoral response. In this review, we will highlight the current understanding of self DNA sensing by cGAS in the context of cancer.

PMID:
31274082
DOI:
10.1051/medsci/2019095

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