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Phytother Res. 2019 Sep;33(9):2152-2162. doi: 10.1002/ptr.6395. Epub 2019 Jul 4.

Devil's claw (Harpagophytum procumbens) and chronic inflammatory diseases: A concise overview on preclinical and clinical data.

Author information

1
Department of Pharmacy, G. D'Annunzio University, Chieti, Italy.
2
Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.
3
Department of Pharmacognosy, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.

Abstract

in English, Italian

Devil's Claw is a traditional medicine that has been long used a wide range of health conditions, including indigestion, fever, allergic reactions, and rheumatism. The main compounds are iridoid glycosides, including harpagoside, harpagide, and procumbide. However, harpagoside is the most responsible for therapeutic activity, and its content is used as reference standard. Here, we analyzed and summarized preclinical and clinical studies focusing on therapeutic efficacy of devil's claw preparations in pathological conditions in which inflammation plays a key causative role.

KEYWORDS:

arthritis; atherosclerosis; inflammatory bowel disease; neurodegenerative diseases; osteoporosis; type 1 diabetes

PMID:
31273865
DOI:
10.1002/ptr.6395
[Indexed for MEDLINE]

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