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Stroke. 2019 Aug;50(8):2118-2124. doi: 10.1161/STROKEAHA.118.023102. Epub 2019 Jul 5.

Stroke Laterality Did Not Modify Outcomes in the HERMES Meta-Analysis of Individual Patient Data of 7 Trials.

Author information

1
From the Department of Clinical Neurosciences, Radiology, and Community Health Sciences; Hotchkiss Brain Institute, and O'Brien Institute for Public Health, Cumming School of Medicine, University of Calgary, Foothills Hospital, Alberta, Canada (M.A.A.).
2
Department of Neurology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia (M.A.A.).
3
Department of Clinical Neurosciences, Radiology, and Community Health Sciences; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Foothills Hospital, Alberta, Canada (M.D.H.).
4
Academic Medical Center, Department of Neurology, Amsterdam, the Netherlands (Y.M.R.).
5
Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Australia (B.C.V.C.).
6
Institute of Neuroscience and Psychology, University of Glasgow, Scotland, United Kingdom (K.W.M.).
7
Departments of Clinical Neurosciences and Radiology (A.M.D.), Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Canada.
8
Department of Diagnostic and Interventional Neuroradiology, INSERM U 947 (S. Bracard), Université de Lorraine and University Hospital of Nancy, France.
9
Stroke Unit, Department of Neurosciences, Hospital Universitari Germans Trias i Pujol, Badalona, Spain (M. Gomis).
10
INSERM CIC 1433 Clinical Epidemiology (F.G.), Université de Lorraine and University Hospital of Nancy, France.
11
Department of Neurology, Stroke Institute, University of Pittsburgh Medical Center, PA (T.G.J.).
12
Departments of Clinical Neurosciences and Radiology (B.K.M.), Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Canada.
13
Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia (P.M.).
14
Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom (P.W.).
15
Department of Radiology, Erasmus MC University Medical Center Rotterdam, the Netherlands (A.v.d.L.).
16
Stroke Center and Department of Neurology, University of California, Los Angeles (J.S.).
17
Altair Biostatistics, St. Louis Park, MN (S. Brown).
18
Departments of Clinical Neurosciences and Radiology (M. Goyal), Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Canada.

Abstract

Background and Purpose- There is contradictory evidence on the impact of the stroke side (hemisphere) on outcomes. We investigated any effect modification by laterality on stroke patients' outcomes in recent endovascular trials. Methods- Individual patient-level data were combined in this meta-analysis of all patients included in randomized trials comparing endovascular thrombectomy predominantly done with stent retrievers with standard care in anterior circulation ischemic patients with stroke (HERMES [Highly Effective Reperfusion Using Multiple Endovascular Devices] Collaboration). We stratified the 90-day functional outcome assessed by ordinal analysis of the modified Rankin Scale according to the stroke side of patients treated with endovascular therapy versus standard care, adjusted for important prognostic variables. Results- The meta-analysis included 1737 patients (871 right hemispheric strokes and 866 left hemispheric) from 7 trials. Baseline median National Institutes of Health Stroke Scale scores were significantly higher in left (20) versus right (16) hemispheric strokes (P<0.001). Other clinical and radiological baseline characteristics were similar. The beneficial response to endovascular therapy assessed by 90-day modified Rankin Scale shift was not modified by the side of the stroke. There were no significant differences between right and left hemispheric stroke in the 90-day functional outcome (modified Rankin Scale score ≤2; 40.7% [95% CI, 37.4%-44.1%] versus 37.6% [95% CI, 37.4%-44.1%]; P=0.19), median final infarct volumes (45 versus 39.5 mL, P=0.51), nor 90-day mortality (15.1% vs 16.8%, P=0.31). Conclusions- Stroke side was not a prognostic factor and did not modify the treatment effect among patients treated in the endovascular or control groups in recent endovascular thrombectomy trials.

KEYWORDS:

meta-analysis; patient; risk; stents; thrombolysis

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