Is Alzheimer's Disease a Neurogenesis Disorder?

Se Hoon Choi; Rudolph E Tanzi

doi:10.1016/j.stem.2019.06.001

Is Alzheimer's Disease a Neurogenesis Disorder?

Cell Stem Cell. 2019 Jul 3;25(1):7-8. doi: 10.1016/j.stem.2019.06.001.

Authors

Se Hoon Choi¹, Rudolph E Tanzi²

Affiliations

¹ Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
² Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. Electronic address: tanzi@helix.mgh.harvard.edu.

PMID: 31271749
DOI: 10.1016/j.stem.2019.06.001

Abstract

The existence of adult hippocampal neurogenesis (AHN) in humans has been controversial. However, recent reports have detected AHN in aged adults and patients with mild cognitive impairment and Alzheimer's disease (AD), suggesting that therapies aimed at promoting AHN may be useful for the prevention and treatment of AD.

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MeSH terms

Adult
Alzheimer Disease*
Healthy Volunteers
Hippocampus
Humans
Middle Aged
Neurogenesis