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Rev Soc Bras Med Trop. 2019 Jun 27;52:e20180502. doi: 10.1590/0037-8682-0502-2018.

Origanum vulgare L. essential oil inhibits the growth of carbapenem-resistant gram-negative bacteria.

Author information

1
Laboratório de Pesquisa em Ciências da Saúde, Universidade Federal da Grande Dourados, Dourados, MS, Brasil.
2
Hospital Universitário de Dourados, Universidade Federal da Grande Dourados, Dourados, MS, Brasil.
3
Fundação Oswaldo Cruz, Campo Grande, MS, Brasil.
4
Universidade Federal do Mato Grosso do Sul, Campo Grande, MS, Brasil.

Abstract

INTRODUCTION:

Plant products are sources for drug development against multidrug resistant bacteria.

METHODS:

The antimicrobial activity of Origanum vulgare L. essential oil (OVeo) against carbapenem-resistant strains was assessed by disk-diffusion, microdilution (REMA-Resazurin Microtiter Assay), and time kill assays.

RESULTS:

Carbapenemase production was confirmed for all strains. OVeo exhibited a minimum inhibitory concentration of 0.059% v/v for Klebsiella pneumoniae and Serratia marcescens, and of 0.015 % v/v for Acinetobacter baumannii. A decrease in cell count was observed after a 4 h treatment.

CONCLUSIONS:

OVeo antimicrobial effect was rapid and consistent, making it a candidate for developing alternative therapeutic options against carbapenem-resistant strains.

PMID:
31271619
DOI:
10.1590/0037-8682-0502-2018
[Indexed for MEDLINE]
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