Format

Send to

Choose Destination
Eur Arch Otorhinolaryngol. 2019 Jul 3. doi: 10.1007/s00405-019-05537-y. [Epub ahead of print]

Prospective evaluation of oral corticosteroid as a predictor of postoperative olfactory recovery after functional endoscopic surgery for nasal polyposis.

Author information

1
Service d'ORL et de chirurgie cervico-faciale, Centre Hospitalier Universitaire de Nantes, Hôtel-Dieu, 1, place A.-Ricordeau, BP 1005, 44093, Nantes cedex 01, France.
2
Service de pneumologie, Centre Hospitalier Universitaire de Nantes, Hôtel-Dieu, 1, place A.-Ricordeau, BP 1005, 44093, Nantes cedex 01, France.
3
Service d'ORL et de chirurgie cervico-faciale, Centre Hospitalier Universitaire de Nantes, Hôtel-Dieu, 1, place A.-Ricordeau, BP 1005, 44093, Nantes cedex 01, France. olivier.malard@chu-nantes.fr.

Abstract

PURPOSE:

Anticipating the possibility of olfactory recovery after functional endoscopic surgery (FES) in nasal polyposis (NP) is difficult. The main objective of this study was to assess the predictive factors of recovering the sense of smell after radical bilateral ethmoidectomy. Secondary objectives were to identify other predictors of olfactory recovery.

METHODS:

Open prospective study was conducted at the Nantes University Hospital including all patients with NP operated on in the Ear, Nose, and Throat Department between January 2011 and September 2017. These patients underwent functional endoscopic surgery (radical ethmoidectomy) after medical treatment failure. Olfaction was quantified prospectively and systematically during the preoperative consultation using a visual analog scale. Multivariate analysis evaluated the presence of predictive factors of postoperative olfactory recovery.

RESULTS:

One hundred nineteen patients were included in the study. Overall, olfaction was partially improved after surgery. For patients who presented greater than 50% recovery of olfaction after systemic corticosteroid therapy before surgery, we observed a predictive better rate of olfactory recovery after surgery (p < 0.001). Age over 65 years, a history of sinonasal surgery, associated asthma, and bacterial colonization were not associated with less postoperative olfactory recovery.

CONCLUSION:

This study identified an objective factor that may influence olfactory recovery after FES using a therapeutic trial for olfactory recovery after oral corticosteroid treatment taken before surgery.

KEYWORDS:

Nasal polyposis; Oral corticosteroid therapy postoperative; Predictive factors; Quality of life; Smell

PMID:
31270597
DOI:
10.1007/s00405-019-05537-y

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center