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J Vet Med Sci. 2019 Jul 2. doi: 10.1292/jvms.19-0006. [Epub ahead of print]

Clinical and pathological characteristics of acute myelogenous leukemia in a female koala with diabetes mellitus.

Author information

1
Hirakawa Zoological Park.
2
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology.
3
The Institute of Environmental Toxicology.
4
Department of Pet Science and Technology, Shandong Vocational Animal Science and Veterinary College.

Abstract

A female koala presented with hyperglycemia related to diabetes mellitus diagnosed at 9 years and treated with insulin. She presented with nasal hemorrhage, anemia, leukocytosis, and tachypnea at 10 years. A blood smear examination revealed scattered, atypical large myeloid cells and a clinical diagnosis of myelogenous leukemia was made. White blood cell count reached a maximum of 295 x 102/μl, with evidence of severe regenerative anemia and thrombocytopenia. Grossly, systemic lymph node enlargement, fragile liver with hemorrhage, and bloody ascites were observed. Histopathologically, atypical myeloid cells, including myelocytic and metamyelocytic cells, were scattered in the vasculature and surrounding tissues throughout the organs. The patient was infected with a koala retrovirus, which might have caused the myelogenous leukemia.

KEYWORDS:

anemia; diabetes; koala; myelogenic leukemia; retrovirus

PMID:
31270282
DOI:
10.1292/jvms.19-0006
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