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Cell Metab. 2019 Jul 2;30(1):14-15. doi: 10.1016/j.cmet.2019.06.012.

A Physiological Function for Ferroptosis in Tumor Suppression by the Immune System.

Author information

1
Department of Biological Sciences, Columbia University, New York, NY 10027, USA; Department of Chemistry, Columbia University, New York, NY 10027, USA. Electronic address: bstockwell@columbia.edu.
2
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: jiangx@mskcc.org.

Abstract

Ferroptosis is a form of regulated cell death involving lethal peroxidation of phospholipids (Hirschhorn and Stockwell, 2019). Recent results reveal that ferroptosis mediates the tumor suppressive activity of interferon gamma secreted by CD8+ T cells in response to immune checkpoint blockade, suggesting the immune system may function in part through ferroptosis to prevent tumorigenesis (Wang et al., 2019).

PMID:
31269423
DOI:
10.1016/j.cmet.2019.06.012

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