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Support Care Cancer. 2019 Jul 3. doi: 10.1007/s00520-019-04955-2. [Epub ahead of print]

Factors associated with muscle function in patients with hematologic malignancies undergoing chemotherapy.

Author information

1
Department of Locomotive Rehabilitation Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
2
Department of Rehabilitation, Nagasaki University Hospital, Nagasaki, Japan.
3
Department of Locomotive Rehabilitation Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. nakano-j@nagasaki-u.ac.jp.
4
Department of Rehabilitation, Michinoo Miyata Orthopaedic Clinic, Nagasaki, Japan.
5
Clinical Research Center, Nagasaki University Hospital, Nagasaki, Japan.
6
Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Abstract

PURPOSE:

Muscle dysfunction such as loss of muscle mass and decreased muscle strength is often observed in patients with hematologic malignancies. However, specific factors associated with muscle function have not been identified. The purpose of this study was to identify significant factors affecting muscle function in patients with hematologic malignancies.

METHODS:

This was a cross-sectional, observational study. Eighty-eight inpatients with hematologic malignancies undergoing chemotherapy were recruited. Participants were evaluated for muscle thickness and isometric knee extensor strength as indicators of muscle function, physical activity, physical symptoms, psychological distress, and self-efficacy at the start date of rehabilitation. Multiple regression analysis with muscle function as the dependent variable and clinical information and other evaluation items as explanatory variables was performed.

RESULTS:

Lymphocyte count, the geriatric nutritional risk index, and physical activity were significant factors associated with muscle thickness, while physical activity and self-efficacy were significant factors associated with isometric knee extensor strength.

CONCLUSIONS:

Nutritional status, physical activity, and self-efficacy were significant factors associated with muscle function in patients with hematologic malignancies. Rehabilitation intervention focusing on improving physical activity and nutritional status should be considered necessary for enhancing muscle function in patients with hematologic malignancies.

KEYWORDS:

Hematologic malignancies; Muscle function; Muscle strength; Nutritional status; Physical activity; Self-efficacy

PMID:
31267281
DOI:
10.1007/s00520-019-04955-2

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