Send to

Choose Destination
Sleep. 2019 Jul 2. pii: zsz137. doi: 10.1093/sleep/zsz137. [Epub ahead of print]

Relationships between objectives sleep parameters and brain amyloid load in subjects at risk to Alzheimer's disease: the INSIGHT-preAD Study.

Author information

Université Côte d'Azur, CoBTeK lab, CMRR CHU, Nice, France.
Institute of Memory and Alzheimer's Disease (IM2A), ICM, INSERM U, CNRS UMR, Pitié-Salpêtrière Hospital, AP-HP, Sorbonne University Paris, France.
Nuclear Medicine Department, Pitié-Salpêtrière Hospital, AP-HP, Sorbonne University Paris, France.
Memory Research and Resources Center for Alzheimer's disease, Department of Neurology, Montpellier University Hospital, and Inserm U1061, and University of Montpellier, Montpellier, France.



Sleep changes have been associated with increased risks of developing cognitive disturbances and Alzheimer's disease (AD). A bidirectional relation is underlined between amyloid-beta (Aß) and sleep disruptions. The sleep profile in participants at risk to develop AD is not fully deciphered. We aim to investigate sleep-wake changes with objective sleep measurements in elderly participants without cognitive impairment depending of their brain amyloid status, positive (Aßpos+) or negative (Aßneg) based on SUVr PET-florbetapir imaging.


68 participants without cognitive impairment who have accepted to be involved in the sleep ancillary study from the InveStIGation of Alzheimer's Predictors in Subjective Memory Complainers (INSIGHT-pre AD) cohort, aiming to record sleep profile based on the analyses of an ambulatory accelerometer-based assessment (7 consecutive 24-hour periods).Neuropsychological tests was performed and sleep parameters have been individualized by actigraph. Participants also underwent a magnetic resonance imaging scan to assess their hippocampal volume. Based on SUVr, PET-florbetapir imaging, two groups Aßpos+ and Aßneg were compared.


Participants were divided into two groups: Aßpos+ (n=24) and Aßneg (n=44). Except for the SUVr, the two subgroups were comparable. When looking to sleep parameters, increased sleep latency, sleep fragmentation (Wake After Sleep Onset (WASO) score and awakenings) and worst sleep efficiency were associated with cortical brain amyloid load.


Actigraphic sleep parameters were associated with cortical brain amyloid load in participants at risk to develop AD.The detection of sleep abnormalities in those participants may be of interest to propose some preventive strategies.


Alzheimer’s disease; MRI neuroimaging; PET- amyloid; Sleep; Sleep/wake patterns; actigraphy; biomarkers; brain amyloid load; florbetapir


Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center