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Nature. 1988 Mar 3;332(6159):40-5.

T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens.

Author information

1
Ludwig Institute for Cancer Research, Lausanne Branch, Epalinges, Switzerland.

Abstract

T lymphocytes reactive with the product of the Mlsa-allele of the minor lymphocyte stimulating (Mls) locus use a predominant T-cell receptor beta-chain variable gene segment (V beta 6). Such V beta 6-bearing T cells are selectively eliminated in the thymus of Mlsa-bearing mice, consistent with a model in which tolerance to self antigens is achieved by clonal deletion.

PMID:
3126397
DOI:
10.1038/332040a0
[Indexed for MEDLINE]

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