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Nature. 1988 Mar 3;332(6159):35-40.

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex.

Author information

1
Howard Hughes Medical Institute, Denver, Colorado.

Abstract

In mice the product of the Mlsa locus is an unusual antigen capable of interaction with certain products of the major histocompatibility locus (MHC) to form a ligand for a large portion of the T-cell alpha/beta receptor repertoire, including nearly all receptors that use V beta 8.1. The presence of Mlsa/MHC during T-cell development results in the deletion of T cells that express V beta 8.1, documenting the importance of clonal deletion in establishing tolerance to self antigens.

PMID:
3126396
DOI:
10.1038/332035a0
[Indexed for MEDLINE]

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