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Elife. 2019 Jul 2;8. pii: e44056. doi: 10.7554/eLife.44056.

Predicting development of adolescent drinking behaviour from whole brain structure at 14 years of age.

Author information

1
Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
2
Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany.
3
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
4
Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
5
University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
6
Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
7
Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
8
Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.
9
NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.
10
Department of Psychiatry, University of Vermont, Burlington, United States.
11
Department of Psychology, University of Vermont, Burlington, United States.
12
Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom.
13
Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany.
14
Physikalisch-Technische Bundesanstalt (PTB), Berlin, Germany.
15
Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry", University ParisSud, University Paris Descartes, Paris, France.
16
Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Canada.
17
Department of Psychology, University of Toronto, Toronto, Canada.
18
Department of Psychiatry, University of Toronto, Toronto, Canada.
19
Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, Germany.
20
Neuroimaging Center,Department of Psychiatry, Technische Universität Dresden, Dresden, Germany.
21
Global Brain Health Institute,School of Psychology, Trinity College Dublin, Dublin, Ireland.

Abstract

Adolescence is a common time for initiation of alcohol use and development of alcohol use disorders. The present study investigates neuroanatomical predictors for trajectories of future alcohol use based on a novel voxel-wise whole-brain structural equation modeling framework. In 1814 healthy adolescents of the IMAGEN sample, the Alcohol Use Disorder Identification Test (AUDIT) was acquired at three measurement occasions across five years. Based on a two-part latent growth curve model, we conducted whole-brain analyses on structural MRI data at age 14, predicting change in alcohol use score over time. Higher grey-matter volumes in the caudate nucleus and the left cerebellum at age 14 years were predictive of stronger increase in alcohol use score over 5 years. The study is the first to demonstrate the feasibility of running separate voxel-wise structural equation models thereby opening new avenues for data analysis in brain imaging.

KEYWORDS:

adolescence; alcohol use; brain structure; human; neuroscience; structural equation modelling, latent growth curve modelling

Conflict of interest statement

SK, AM, AB, UB, EQ, SD, HF, AG, HG, PG, AH, BI, JM, FN, DP, TP, LP, SM, JF, MS, HW, RW, GS, UL, JG No competing interests declared, TB Has served as an advisor or consultant to Bristol-Myers Squibb, Desitin Arzneimittel, Eli Lilly, Medice, Novartis, Pfizer, Shire, UCB, and Vifor Pharma; he has received conference attendance support, conference support, or speaking fees from Eli Lilly, Janssen McNeil, Medice, Novartis, Shire, and UCB; and he is involved in clinical trials conducted by Eli Lilly, Novartis, and Shire; the present work is unrelated to these relationships. CB Reviewing editor, eLife

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