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Biomed Pharmacother. 2019 Sep;117:109183. doi: 10.1016/j.biopha.2019.109183. Epub 2019 Jun 28.

A dual synergistic of curcumin and gelatin on thermal-responsive hydrogel based on Chitosan-P123 in wound healing application.

Author information

1
Institute of Research and Development, Duy Tan University, Da Nang City, 550000, Viet Nam; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Hochiminh City, 700000, Viet Nam.
2
Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Hochiminh City, 700000, Viet Nam; International University, National Universities in Hochiminh, Hochiminh City, 700000, Viet Nam.
3
Ajou University Medical Center, Ajou University, 5 Wonchon, Yeoungtong, Suwon, 443-749, Republic of Korea.
4
International University, National Universities in Hochiminh, Hochiminh City, 700000, Viet Nam.
5
Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Hochiminh City, 700000, Viet Nam; Graduate University of Science and Technology Viet Nam, Vietnam Academy of Science and Technology, Hochiminh City, 700000, Viet Nam.
6
Institute of Research and Development, Duy Tan University, Da Nang City, 550000, Viet Nam.
7
NTT Hi-Tech Institute, Nguyen Tat Thanh University, 300A Nguyen Tat Thanh, Ward 13 district 4, Ho Chi Minh city, 700000, Viet Nam. Electronic address: blgiang@ntt.edu.vn.
8
Graduate University of Science and Technology Viet Nam, Vietnam Academy of Science and Technology, Hochiminh City, 700000, Viet Nam; Ba Ria-Vung Tau University, 80 Truong Cong Dinh, Ward 3, Vung Tau City, 78000, Viet Nam.
9
Institute of Research and Development, Duy Tan University, Da Nang City, 550000, Viet Nam; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Hochiminh City, 700000, Viet Nam; Graduate University of Science and Technology Viet Nam, Vietnam Academy of Science and Technology, Hochiminh City, 700000, Viet Nam. Electronic address: tnquyen@iams.vast.vn.

Abstract

This study aimed to fabricate the potential therapeutic scaffold to efficiently and safely fastening skin wound healing. A biocompatible grafting polymer-based thermal sensitive hybrid hydrogel (Chitosan-P123, CP) containing gelatin and curcumin was designed to be suitable stiffness for tissue regeneration. A detailed in the rheological study found that the encapsulated agents induced the change in the stiffness of the hydrogel from the hard to the soft. Especial, the thermally induced phase transition of CP hydrogel was governed by the participant of gelatin rather than curcumin. For example, at 25 wt% gelatin, CP hydrogel exhibited a unique gel-sol-gel transition following the function of temperature. Moreover, in vitro investigation revealed that the hybrid hydrogel provides the capacity of especially induced curcumin release with a sustainable rate as well as the excellent biocompatibility scaffold. Altogether with in vivo study, the hybrid hydrogel highlighted the advance of the dual synergistic of curcumin and gelatin in development of smart scaffold system, which promoted the efficacy in the regeneration of the structure and the barrier's function of damaged skin such as wound or skin cancer.

KEYWORDS:

Chitosan-Pluronic P123; Dual loading; Thermosensitive hydrogel; Wound healing

PMID:
31261029
DOI:
10.1016/j.biopha.2019.109183
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