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J Sci Food Agric. 2019 Jul 1. doi: 10.1002/jsfa.9903. [Epub ahead of print]

Effect of Egg Consumption on Inflammatory Markers: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials.

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Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


There is little evidence whether eggs affect inflammation. The aim of this meta-analysis was to explore the effects of egg consumption on inflammation. A systemic search of online databases (ISI, Scopus, Ovid, PubMed, Cochrane) was used to gather clinical trials that assessed the effect of egg consumption on circulating inflammatory biomarkers from inception up to April 2019. Using a random-effects model, pooled weighted mean differences (WMD) and corresponding standard deviations (SD) were calculated. Of the 21 total references found, 9 trials (8 trials assessed high sensitivity C-Reactive Protein (hs-CRP), 4 trials assessed Interleukin-6 (IL-6) and 5 trials assessed Tumor necrosis factor alpha (TNF-α)) were eligible for analysis. Egg consumption did not affect hs-CRP (WMD 0.24 mg/L; 95% CI: -0.43, 0.90; I2 = 53.8; P= 0.48), IL-6 (WMD 0.20 pg/mL; 95% CI: -0.71, 1.11; I2 = 69.3; P= 0.50), and TNF-α (WMD: -0.38 pg/mL; 95% CI: -0.87, 0.10; I2 = 0.00; P= 0.12) relative to controls. Overall, this meta-analysis revealed that egg consumption had no significant effect on serum biomarkers of inflammation in adults. This article is protected by copyright. All rights reserved.


Egg; Inflammation; Meta-analysis; Randomized controlled trial; Systematic review


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