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Cureus. 2019 Apr 18;11(4):e4497. doi: 10.7759/cureus.4497.

Correlation Between Vitamin D Deficiency and Diabetic Ketoacidosis.

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Cardiology, University of Illinois at Chicago, Chicago, USA.
Internal Medicine, Nishtar Medical College, Multan, PAK.
Internal Medicine, Liaquat University of Medical and Health Sciences, Hyderabad, PAK.
Internal Medicine, Ghulam Mohammad Mahar Medical College, Sukkur, PAK.


Both type 1 and type 2 diabetes mellitus have been associated with vitamin D deficiency. Diabetic ketoacidosis, which is a complication of type 1 and, rarely, type 2 diabetes, is also found to be associated with vitamin D levels. This review discusses studies on the correlation between diabetic ketoacidosis and vitamin D levels. Studies show that vitamin D deficiency is associated with the occurrence of diabetic ketoacidosis. Diabetic ketoacidosis is also found to affect vitamin D levels. The possible explanation of diabetic ketoacidosis affecting vitamin D levels is the inactivity of the 1-alpha-hydroxylase enzyme and an increase in the renal excretion of vitamin D binding proteins. The presence of vitamin D receptors on pancreatic beta cells explains the role of vitamin D in the causation of diabetic ketoacidosis.


diabetic ketoacidosis; type 1 diabetes; vitamin d levels

Conflict of interest statement

The authors have declared that no competing interests exist.

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