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Cureus. 2019 Apr 18;11(4):e4497. doi: 10.7759/cureus.4497.

Correlation Between Vitamin D Deficiency and Diabetic Ketoacidosis.

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1
Cardiology, University of Illinois at Chicago, Chicago, USA.
2
Internal Medicine, Nishtar Medical College, Multan, PAK.
3
Internal Medicine, Liaquat University of Medical and Health Sciences, Hyderabad, PAK.
4
Internal Medicine, Ghulam Mohammad Mahar Medical College, Sukkur, PAK.

Abstract

Both type 1 and type 2 diabetes mellitus have been associated with vitamin D deficiency. Diabetic ketoacidosis, which is a complication of type 1 and, rarely, type 2 diabetes, is also found to be associated with vitamin D levels. This review discusses studies on the correlation between diabetic ketoacidosis and vitamin D levels. Studies show that vitamin D deficiency is associated with the occurrence of diabetic ketoacidosis. Diabetic ketoacidosis is also found to affect vitamin D levels. The possible explanation of diabetic ketoacidosis affecting vitamin D levels is the inactivity of the 1-alpha-hydroxylase enzyme and an increase in the renal excretion of vitamin D binding proteins. The presence of vitamin D receptors on pancreatic beta cells explains the role of vitamin D in the causation of diabetic ketoacidosis.

KEYWORDS:

diabetic ketoacidosis; type 1 diabetes; vitamin d levels

Conflict of interest statement

The authors have declared that no competing interests exist.

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