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J Neurol. 2019 Oct;266(10):2505-2511. doi: 10.1007/s00415-019-09448-0. Epub 2019 Jun 29.

Prospective memory in Parkinson's disease: the role of the motor subtypes.

Author information

1
Department of Psychology, University of Campania "Luigi Vanvitelli", Caserta, Italy.
2
Department of Motor Sciences and Wellness, University "Parthenope", Naples, Italy.
3
Institute of Diagnosis and Health, IDC-Hermitage Capodimonte, Naples, Italy.
4
Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy.
5
Salvatore Maugeri Foundation, Scientific Institute of Telese, Telese Terme, Italy.
6
Department of Psychology, University of Campania "Luigi Vanvitelli", Caserta, Italy. gabriella.santangelo@unicampania.it.

Abstract

BACKGROUND:

Prospective memory (PM) is defined as memory for future intentions and it is typically divided into time-based and event-based PM. Deficit of PM has been reported in patients with Parkinson's disease (PD) but no study has yet explored the association between motor subtypes (tremor dominant and rigidity/bradykinesia dominant) and performance on PM tasks. The aim of the study was to explore the role of motor subtypes in the defect of PM.

METHODS:

Consecutive outpatients with tremor dominant (TD-PD) or rigidity/bradykinesia dominant (PIGD-PD) PD and healthy subjects (HCs) were enrolled and underwent a neuropsychological battery assessing PM, verbal memory and executive functions and questionnaires assessing apathy, functional autonomy, and perceived memory disturbances.

RESULTS:

We enrolled 28 patients with TD-PD, 28 patients with PIGD-PD and 50 HCs. The three groups did not differ on demographic and cognitive variables. Patients with TD-PD performed worse on time-based PM tasks than patients with PIGD-PD and HCs; no significant difference was found among the three groups on event-based PM tasks. Executive dysfunctions contributed to reduced time-based PM scores in TD-PD. Moreover, severe deficit of time-based and more frequency of perceived failures of PM contributed to reduced functional autonomy in TD-PD.

CONCLUSION:

The finding of a poorer performance of patients with TD-PD than ones with PIGD-PD and HCs suggests a selective deficit of time-based PM abilities in TD-PD group; therefore, deficit of time-based PM might be considered as a distinctive non-motor symptom of TD-PD and it might affect the functional autonomy in this subtype of PD.

KEYWORDS:

Cognitive dysfunctions; Parkinson’s disease; Postural instability/gait difficulty subtype; Prospective memory; Tremor dominant subtype

PMID:
31256281
DOI:
10.1007/s00415-019-09448-0

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