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Aging (Albany NY). 2019 Jun 29;11(12):4216-4237. doi: 10.18632/aging.102048.

β-catenin-mediated hair growth induction effect of 3,4,5-tri-O-caffeoylquinic acid.

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School of Integrative and Global Majors (SIGMA) University of Tsukuba, Tsukuba City, 305-8572 Japan.
Faculty of Life and Environmental Sciences University of Tsukuba, Tsukuba City, 305-8572 Japan.
Alliance for Research on the Mediterranean and North Africa (ARENA) University of Tsukuba, Tsukuba City, 305-8572 Japan.


The hair follicle is a complex structure that goes through a cyclic period of growth (anagen), regression (catagen), and rest (telogen) under the regulation of several signaling pathways, including Wnt/ β-catenin, FGF, Shh, and Notch. The Wnt/β-catenin signaling is specifically involved in hair follicle morphogenesis, regeneration, and growth. β-catenin is expressed in the dermal papilla and promotes anagen induction and duration, as well as keratinocyte regulation and differentiation. In this study, we demonstrated the activation of β-catenin by a polyphenolic compound 3,4,5-tri-O-caffeoylquinic acid (TCQA) in mice model and in human dermal papilla cells to promote hair growth cycle. A complete regrowth of the shaved area of C3H mice was observed upon treatment with TCQA. Global gene expression analysis using microarray showed an upregulation in hair growth-associated genes. Moreover, the expression of β-catenin was remarkably upregulated in vivo and in vitro. These findings suggest that β-catenin activation by TCQA promoted the initiation of the anagen phase of the hair cycle.


3,4,5-tri--caffeoylquinic acid (TCQA) O; Wnt/ β-catenin pathway; anagen; dermal papilla; β-catenin

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