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J Cell Physiol. 2019 Jun 28. doi: 10.1002/jcp.29004. [Epub ahead of print]

Human umbilical cord mesenchymal stem cell-derived extracellular vesicles: A novel therapeutic paradigm.

Author information

1
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
2
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
3
Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
4
Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Abstract

Mesenchymal stem cells (MSCs) have been revealed to hold great potential for the development of new treatment approaches for various diseases. However, the clinical use of these cells is limited due to their tumorigenic effects. The therapeutic benefits of MSCs are largely dependent on paracrine factors including extracellular vesicles (EVs). EVs are nano-sized bilayer membrane structures containing lipids, microRNAs and proteins which play key roles in cell-to-cell communications. Because of their lower immunogenicity, tumorigenicity, and easier management, EVs have emerged as a new promising alternative to whole-cell therapy. Therefore, this paper reviews current preclinical studies on the use of EVs derived from human umbilical cord MSCs (hucMSCs) as a therapeutic approach in treatment of several diseases including neurological, cardiovascular, liver, kidney, and bone diseases as well as the cutaneous wound, inflammatory bowel disease, cancers, infertility, and other disorders.

KEYWORDS:

exosomes; extracellular vesicles; hucMSCs; microvesicles; regenerative medicine

PMID:
31254289
DOI:
10.1002/jcp.29004

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