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J Diabetes Complications. 2019 Jun 3. pii: S1056-8727(19)30197-7. doi: 10.1016/j.jdiacomp.2019.05.023. [Epub ahead of print]

Serum uromodulin is associated with urinary albumin excretion in adolescents with type 1 diabetes.

Author information

1
Section of Endocrinology, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO, United States.
2
Section of Endocrinology, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO, United States; Section of Nephrology, Department of Medicine, University of Colorado Denver School of Medicine, Aurora, CO, United States; Barbara Davis Center for Childhood Diabetes, University of Colorado Denver School of Medicine, Aurora, CO, United States.
3
Section of Nephrology, Department of Medicine, University of Colorado Denver School of Medicine, Aurora, CO, United States.
4
Section of Endocrinology, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO, United States; Department of Biostatistics and Informatics, University of Colorado Denver School of Public Health, Aurora, CO, United States.
5
Department of Nephrology, University of Toronto School of Medicine, Ontario, Canada.
6
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver School of Medicine, Aurora, CO, United States.
7
Section of Endocrinology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, United States; Stanford Diabetes Research Center, Stanford University School of Medicine, Stanford, CA, United States.
8
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver School of Medicine, Aurora, CO, United States. Electronic address: Paul.Wadwa@ucdenver.edu.

Abstract

Early diabetic kidney disease (DKD) occurs in adolescents with type 1 diabetes (T1D). Lower serum uromodulin (SUMOD) predicts DKD progression in adults with T1D. In this study, we demonstrate that lower SUMOD is associated with urinary albumin excretion in adolescents with T1D, suggesting a potential relationship between SUMOD and early kidney dysfunction in T1D youth.

KEYWORDS:

Adolescents; Arterial stiffness; Glomerular filtration rate; Serum uromodulin; Type 1 diabetes; Urinary albumin excretion

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