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Nutrients. 2019 Jun 27;11(7). pii: E1466. doi: 10.3390/nu11071466.

A Double-Blind, Randomized, Placebo-Controlled Crossover Clinical Study of the Effects of Alpha-s1 Casein Hydrolysate on Sleep Disturbance.

Author information

1
Sleep Center, Ewha Womans University Mokdong Hospital, Seoul 07985, Korea.
2
Departments of Neurology, Ewha Womans University School of Medicine and Ewha Medical Research Institute, Seoul 07804, Korea.
3
Departments of Medical Science, Ewha Womans University School of Medicine and Ewha Medical Research Institute, Seoul 07804, Korea.
4
INGREDIA Co., Ltd., CEDEX, 62000 Arras, France.
5
Departments of Molecular Medicine, Ewha Womans University School of Medicine and Ewha Medical Research Institute, Seoul 07804, Korea.
6
Sleep Center, Ewha Womans University Mokdong Hospital, Seoul 07985, Korea. leeh@ewha.ac.kr.
7
Departments of Neurology, Ewha Womans University School of Medicine and Ewha Medical Research Institute, Seoul 07804, Korea. leeh@ewha.ac.kr.

Abstract

This study evaluated the effects of alpha-s1 casein hydrolysate (ACH; Lactium®) on the subjective and objective sleep profiles of a community-based sample of Koreans with poor sleep quality. We performed a double-blind, randomized crossover trial with 48 participants (49.0 ± 1.7 years old, 65% female) who exhibited a mild to moderate degree of sleep disturbance. Either ACH or placebo was administered for the initial four weeks, and the counterpart was administered in precisely the same manner after a four-week washout period. Sleep disturbance scales, daytime functioning, and psychiatric aspects showed a similar tendency to improve during both ACH and placebo phases without significant group differences. Overall perceived sleep profiles in sleep diaries were significantly improved during the ACH phase, represented by increased total sleep time and sleep efficiency (SE), as well as decreased sleep latency and wake after sleep onset (WASO). Interestingly, actigraphy demonstrated significantly increased SE after continuous use of ACH for four weeks, clearly more improved when compared to two weeks of use. The polysomnography measures showed a similar tendency without statistically significant group differences. Our findings suggest that refined ACH was well tolerated and could improve sleep quality, with possible cumulative beneficial effects with long-term administration.

KEYWORDS:

Lactium®; alpha-s1 casein hydrolysate; clinical trial; insomnia; nutritional supplements; sleep disturbance; sleep quality

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