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J Dermatolog Treat. 2019 Jun 28:1-10. doi: 10.1080/09546634.2019.1623860. [Epub ahead of print]

Patient and physician preferences for atopic dermatitis injection treatments in Japan.

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a Department of Dermatology , Tokyo Medical University , Tokyo , Japan.
b Community and Patient Preference Research Pty Ltd (CaPPRe) , Sydney , Australia.
c Sanofi K.K , Tokyo , Japan.


Background: Recently, biologic agents administered as a subcutaneous injection have been introduced as treatment options for atopic dermatitis (AD). Biologic treatments differ considerably from traditional topical and systemic anti-inflammatory treatments, and it is unclear how this may impact patient and physician preferences for treatments. Objective: To examine the treatment preferences for new injection treatments of patients and physicians. Methods: Discrete choice experiment methodology was used to quantify preferences for treatments via an online survey. Participants were presented with a series of choice scenarios; treatment options were described using the following attributes: add-on or replacement treatment, efficacy of improving rashes and itching, time until response, place of administration, injection site reaction, risk of mild-to-moderate and severe side effects, frequency of administration and cost. Results: 76.67% of physicians and 46.24% of patients opted-in to the new treatment in the scenarios presented. Of those who opted-in to treatment, physicians were more likely to value the efficacy of treating rashes and were more concerned about cost than patients. Patients preferred add-on treatments and were against self-administering the treatment at home. Conclusion: Overall patients and physicians differ in their preferences for AD treatments. These findings have implications for shared decision making and clinical practice.


Atopic dermatitis; biologics; discrete choice experiment; treatment preference

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