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Eur J Immunol. 2019 Jun 28. doi: 10.1002/eji.201848083. [Epub ahead of print]

Identification of an IRF3 variant and defective antiviral interferon responses in a patient with severe influenza.

Author information

1
Department of Infectious Diseases, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200, Aarhus N, Denmark.
2
Department of Biomedicine, Aarhus University, Bartholins alle 6, 8000, Aarhus C, Denmark.
3
Department of Molecular Biology and Genetics, C.F. Møllers Allé 3, 8000, Aarhus C, Denmark.
4
Department of Intensive Care, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200, Aarhus N, Denmark.
5
Department of Clinical Immunology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200, Aarhus N, Denmark.
6
Department of Molecular Biology and Genetics, Gustav Wieds Vej 10, 8000, Aarhus C, Denmark.
7
Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 82, 8200, Aarhus N, Denmark.

KEYWORDS:

IRF3; Influenza; Innate immunity; Interferon; Primary immunodeficiency

PMID:
31250433
DOI:
10.1002/eji.201848083

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