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Bioinformation. 2019 Apr 30;15(5):315-320. doi: 10.6026/97320630015315. eCollection 2019.

Annotation of a hypothetical protein (WP_002969292.1) from Brucella abortus.

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Department of Biotechnology, Hemvati Nandan Garhwal University, Srinagar Garhwal, Uttarakhand-246174, India.


Brucellosis is a zoonotic disease caused mainly by the bacteria belonging to the genus Brucella, most common of them is Brucella abortus. Genome sequencing of Brucella was completed in 2005. While majority of the proteins were assigned function, a large number of the peptides remained un-annotated and were referred as 'hypothetical'. These hypothetical proteins may contain crucial information about the biology and pathogenesis of the B. abortus. Therefore, it is of interest to annotate one such hypothetical protein as a multiple antibiotic resistance regulator protein, MarR. The physiological parameters, localization and the structural features were predicted for this protein which corroborated as the winged-helix type DNA-binding domain superfamily of transcription factors.


Annotation; Brucella abortus; hypothetical protein

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