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Med Gas Res. 2019 Apr-Jun;9(2):88-92. doi: 10.4103/2045-9912.260650.

The role of hydrogen sulfide in gastric mucosal damage.

Author information

1
Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
2
Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.

Abstract

Gastrointestinal disease is a major global threat to public health. In the past few decades, numerous studies have focuses on the application of small molecule gases in the disease treatment. Increasing evidence has shown that hydrogen sulfide (H2S) has anti-inflammatory and anti-oxidative effects, and can regulate gastric mucosal blood flow in the gastric mucosa. After gastric mucosa damage, the level of H2S in the stomach decreases. Administration of H2S can protect and repair the damaged gastric mucosa. Therefore, H2S is a new target for the repair and treatment of gastric mucosa damage. In this review, we introduce the roles of H2S in the treatment of gastric mucosa damage and provide the potential strategies for further clinical treatment.

KEYWORDS:

anti-inflammation; anti-oxidation; carbon monoxide; experimental study; gastric mucosa; gastric mucosal blood flow; hydrogen sulfide; nitric oxide; protective effects

PMID:
31249257
DOI:
10.4103/2045-9912.260650
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