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Indian J Med Res. 2019 Mar;149(3):418-422. doi: 10.4103/ijmr.IJMR_1388_17.

Retrospective analysis of colistin-resistant bacteria in a tertiary care centre in India.

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Department of Critical Care Medicine, Apollo Hospitals, Bhubaneswar, India.
Department of Microbiology, Apollo Hospitals, Bhubaneswar, India.


The incidence of carbapenem-resistant Enterobacteriaceae has been steadily rising. The morbidity, mortality and financial implications of such patients are significant. We did a retrospective analysis of the case records of 11 patients who had culture report positive for pan drug-resistant (PDR) organisms. There were total 15 isolates of PDR organisms in 11 patients. These were associated with catheter-associated urinary tract infections (7), tracheitis (4), bacteraemia (2), meningitis (1) and soft-tissue infection (1). Average APACHE II score was 23.72 (range 7-36) indicating patients with multiple co-morbidities and organ dysfunction. The average length of hospital stay was 60.72 (25-123) days. The overall mortality rate was 81.81 per cent, while PDR infection-related mortality was 18.18 per cent. Strict implementation of antibiotic stewardship programme is essential to limit use and prevent abuse of colistin.


Antibiotic abuse - carbapenem resistance - colistin - mortality - pan drug-resistance

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