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Biochem J. 1987 Dec 1;248(2):483-7.

Platelet-reactive sites in collagen. Collagens I and III possess different aggregatory sites.

Author information

1
Strangeways Research Laboratory, Cambridge, U.K.

Abstract

Collagen type III possesses a highly reactive platelet-aggregatory site at a locus which in type I is essentially inactive whilst the latter collagen possesses reactive sites absent in type III. It is proposed that platelet aggregation by collagen involves the sequence GK[or R]PG(EY)GPK[or R]G(EY) or, less favourably, GPK[or R]G(EY)G(XY)GK[or R]PG(EY), one basic residue acting in combination with the second in an adjacent alpha-chain.

PMID:
3124815
PMCID:
PMC1148567
DOI:
10.1042/bj2480483
[Indexed for MEDLINE]
Free PMC Article

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