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IEEE Trans Biomed Eng. 2019 Jun 24. doi: 10.1109/TBME.2019.2924440. [Epub ahead of print]

A Wireless Handheld Pressure Measurement System for in vivo Monitoring of Intraocular Pressure in Rabbits.

Abstract

Intraocular pressure (IOP) is the leading modifiable risk factor for preventing vision loss in glaucoma patients. Direct and frequent IOP measurements are highly desirable to assess adequacy of treatment and prevent further vision loss. In this study, we report on successful in vivo measurements of intraocular pressure in rabbits using an optical IOP measurement system. The sensor was implanted during cataract surgery in two New Zealand white (NZW) rabbits and tested in vivo for 10 weeks. Prior to implantation, the sensors were characterized in vitro in the physiologically relevant pressure range of 0 mmHg to 60 mmHg. A portable wireless handheld reader consisting of an internal beam splitter, a monochromatic light source, and a digital single-lens reflex (DSLR) camera was also designed and implemented to capture interference patterns from the sensor. The sensitivity and accuracy of the sensor was 30 nm/mmHg and ±0.2 mmHg, respectively. Ten weeks post-implantation, the two New Zealand white rabbits continued to respond well to the implant with no observable inflammation, signs of infection, or biofouling. All IOP measurements were obtained using the portable DSLR handheld reader. Successful in vivo studies demonstrate biocompatibility of the IOP sensor and prove feasibility of the IOP measurement system. The system has the potential to be used in both clinical and patient point-of-care (home) settings to frequently and accurately measure pressure.

PMID:
31247540
DOI:
10.1109/TBME.2019.2924440

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