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Biomed Pharmacother. 2019 Jun 24;117:109138. doi: 10.1016/j.biopha.2019.109138. [Epub ahead of print]

Research progress in the relationship between type 2 diabetes mellitus and intestinal flora.

Author information

1
School of Chinese Materia Medica, Beijing University of Chinese Medicine, No.11 North 3rd Ring East Road, Chao-Yang District, Beijing, 100029, China.
2
National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, No.8 Hong-Da Middle Road, Da-Xing District, Beijing, 100176, China.
3
Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, No. 11 North 3rd Ring East Road, Chao-Yang District, Beijing, 100029, China.
4
Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, No. 11 North 3rd Ring East Road, Chao-Yang District, Beijing, 100029, China. Electronic address: wangting1973@sina.com.
5
Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, No. 11 North 3rd Ring East Road, Chao-Yang District, Beijing, 100029, China. Electronic address: zhaobs1973@163.com.

Abstract

Type 2 diabetes mellitus (T2DM) is a common clinical chronic disease, while its pathogenesis is still inconclusive. Intestinal flora, the largest micro-ecological system in the human body, is involved in, meanwhile has a major impact on the body's material and energy metabolism. Recent studies have shown that in addition to obesity, genetics, and islet dysfunction, the disturbance of intestinal flora may partly give rise to diabetes. In this paper, we summarized the current research on the correlation between T2DM and intestinal flora, and concluded the pathological mechanisms of intestinal flora involved in T2DM. Moreover, the ideas and methods of prevention and treatment of T2DM based on intestinal flora were proposed, providing theoretical basis and literature reference for the treatment of T2DM and its complications based on the regulation of intestinal flora.

KEYWORDS:

Intestinal flora; Research progress; Type 2 diabetes mellitus

PMID:
31247468
DOI:
10.1016/j.biopha.2019.109138
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