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RMD Open. 2019 May 28;5(1):e000918. doi: 10.1136/rmdopen-2019-000918. eCollection 2019.

Evaluation of the performances of 'typical' imaging abnormalities of axial spondyloarthritis: results of the cross-sectional ILOS-DESIR study.

Author information

1
Rheumatology, Hopital Cochin, Paris, France.
2
INSERM (U1153): Clinical Epidemiology and Biostatistics PRES Sorbonne Paris-Cité, Paris, France.
3
INSERM UMR S1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Sorbonne Université, Paris, France.
4
Rheumatology, Hopital Universitaire Pitie Salpetriere, Paris, France.
5
Physical Medicine and Rehabilitation, Cochin Hospital, Paris, France.
6
Private Practice, Paris, France.
7
Radiology, Lariboisière Hospital, Paris, France.
8
Rheumatology, Hopital Lariboisiere, Paris, France.
9
Inserm UMR1132 Bioscar, Universite Paris Diderot UFR de Medecine, Paris, France.
10
Rheumatology, CHU Bichat Claude Bernard, Paris, France.
11
INSERM U699, Bichat Faculty of Medicine, Université Paris Diderot, PRES Sorbonne Paris Cité, Paris, France.
12
Rheumatology, Trousseau University Hospital, Tours, France.
13
Radiology Department, Cochin Hospital, Assistance Publique Hôpitaux de Paris, Paris, France.

Abstract

Objective:

To evaluate the prevalence and performance as axial Spondyloarthritis (axSpA) diagnostic feature of radiographic and MRI lesions 'typical' of axSpA of the sacroiliac joint (SIJ) and spine in a mechanical chronic back pain (CBP) population and in an axSpA cohort.

Methods:

Cross-sectional multicentre study. Patients: (1) recent onset axSpA (DESIR cohort) and (2) mechanical non-axSpA CBP matched for age and gender (ILOS study). Imaging: radiographs and MR scans were performed identically in both groups. All images were centrally read, blinded for diagnosis and for other imaging findings in the same patient. Statistical analysis: prevalence of lesions 'typical of axSpA' were compared in both groups. Sensitivity, specificity and positive likelihood ratios (LR+) of each lesion (and combination of lesions) were calculated.

Results:

A total of 98 patients with CBP were included, and compared with 100 patients with recent onset axSpA. SIJ lesions were consistently more frequent in the axSpA group (35.0% vs 11.8% p<0.001, 35.0% vs 8.4% p<0.001% and 32.0% vs 10.0%. p<0.001 for modified New York criteria, MRI sacroiliitis and ≥3 erosions of the SIJ on MRI, respectively), and performed well (LR+ for ≥3 erosions 3.0 (95% CI 1.6 to 5.8)). Spine lesions were comparable across groups: radiographic lesions were rare, while all MRI lesions were frequent.

Conclusion:

Our study confirms that 'typical' lesions can also be observed in patients with non-axSpA CBP but that SIJ lesions by all modalities remain the most valuable for diagnosis, including structural lesions of the SIJ. This suggests the potential interest of adding MRI SIJ structural lesions in the definition of MRI abnormalities for axSpA classification.

KEYWORDS:

epidemiology; magnetic resonance imaging; spondyloarthritis

Conflict of interest statement

Competing interests: AM received an ASAS (Assessment of SpondyloArthritis International Society) research grant and an unrestricted grant from Pfizer (Passerelle) to conduct this study. There are no other benefits from commercial sources for the work reported on in the manuscript, and no other financial interests that any of the authors may have, which could create a potential conflict of interest or the appearance of a conflict of interest with regard to the work.

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