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Curr Mol Med. 2019;19(8):589-596. doi: 10.2174/1566524019666190627122655.

The Effect of Interleukin 38 on Inflammation-induced Corneal Neovascularization.

Author information

1
The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, 453000, China.
2
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.
3
Guangdong Science and Technology Library (Guangdong Institute of Scientific and Technical Information and Development Strategy), China.
4
Institute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, Henan, 453000, China.

Abstract

BACKGROUND:

Angiogenesis is tightly linked to inflammation. Cytokines of interleukin 1 (IL-1) family are key mediators in modulating inflammatory responses.

METHODS:

In this study, we examined the role of IL-38, a member of the IL-1 family, in mediating inflammation-induced angiogenesis.

RESULTS:

The results showed that the angiogenesis was attenuated by topical administration of IL-38 to the injured corneas in a mouse model of alkali-induced corneal neovascularization (CNV). Further study showed that the expression of inflammatory cytokines TNF-α, IL-6, IL-8 and IL-1β was decreased in the IL-38-treated corneas. Moreover, the angiogenic activities including the proliferation, migration and tube formation of human retinal endothelial cells were reduced by IL-38 treatment in vitro.

CONCLUSION:

The data indicate that IL-38 modulates inflammation-induced angiogenesis.

KEYWORDS:

Angiogenesis; IL-38; cytokine; inflammation; interleukin; neovascularization.

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