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Curr Stem Cell Res Ther. 2019;14(8):683-697. doi: 10.2174/1574888X14666190617143952.

Stem Cells in Rotator Cuff Injuries and Reconstructions: A Systematic Review and Meta-Analysis.

Author information

1
Department of Orthopaedics, Shandong Provincial Hospital Affiliated to Shandong University, No.324, Road Jing Wu Wei Qi, Jinan 250021, Shandong, China.
2
Department of Orthopaedics, Guangzhou Red Cross Hospital, Jinan University, Tongfu road 396, Haizhu district, Guangzhou, China.
3
Department of Trauma Surgery, University of Regensburg, Am biopark 9, 93049 Regensburg, Germany.

Abstract

BACKGROUND:

Multiple studies have focused on stem cell-based treatments for rotator cuff disorders; however, the outcomes are not consistent.

OBJECTIVES:

This systematic review and meta-analysis were performed to evaluate the effects of stem cells on rotator cuff healing.

METHODS:

A detailed search of relevant studies was conducted in three databases including Pubmed/ Medline, Cochrane library, and Embase databases, using the following keywords: "rotator cuff" or "Tissue Engineering" AND "stem cell" from inception to January 01, 2019. The standard mean difference (SMD) and 95% confidence interval (CI) for each individual study were extracted from the original studies or calculated based on relevant data and pooled to obtain integrated estimates using random effects modeling.

RESULTS:

A total of 22 studies were identified. The results demonstrated that the ultimate strain in the stem cell group was significantly higher than that in the control group at 4 and 8 weeks. Muscle weight in the stem cell group was higher than the control group at 8 weeks, while no significant differences were detected at 16 weeks. The stem cell group had lower visual analog scale scores (VAS) at 1, 3, and 6 months, and higher American shoulder and elbow surgeons score (ASES) at 3 months. In addition, the walking distance, time, and speed in the stem cell group were significantly superior to those in the control group.

CONCLUSIONS:

This meta-analysis confirms that stem cells improved the rehabilitation of rotator cuff disorders. However, larger-scale studies are needed to further support these findings.

KEYWORDS:

Rotator cuff; meta-analysis; regenerative therapy; rotator cuff disorders; stem cell; tissue engineering.

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