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Int J Stem Cells. 2019 Jul 31;12(2):227-239. doi: 10.15283/ijsc19006.

Application of Nanotechnology in Targeting of Cancer Stem Cells: A Review.

Author information

1
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
2
International affairs, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
3
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
4
Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

Cancer is increasingly apparent as a systems-level, network happening. The central tendency of malignant alteration can be described as a two-phase procedure, where an initial increase of network plasticity is followed by reducing plasticity at late stages of tumor improvement. Cancer stem cells (CSCs) are cancer cells that take characteristics associated with normal stem cells. Cancer therapy has been based on the concept that most of the cancer cells have a similar ability to separate metastasise and kill the host. In this review, we addressed the use of nanotechnology in the treatment of cancer stem cells.

KEYWORDS:

Cancer stem cell; Markers; Nanomaterial; Signaling pathway; Targeting

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