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Acta Paediatr. 2020 Jan;109(1):71-77. doi: 10.1111/apa.14913. Epub 2019 Jul 15.

Delayed cord clamping was not associated with an increased risk of hyperbilirubinaemia on the day of birth or jaundice in the first 4 weeks.

Author information

1
International Maternal and Child Health, Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
2
Department of Paediatrics, Region Halland, Halmstad, Sweden.
3
Health Section, UNICEF, UN House, Lalitpur, Nepal.
4
Department of Clinical Sciences Lund, Pediatrics/Neonatology, Skåne University Hospital, Lund University, Lund, Sweden.

Abstract

AIM:

Our aim was to investigate the effects of timing of cord clamping on the risk of hyperbilirubinaemia.

METHODS:

We recruited 540 normal vaginal deliveries at the Paropakar Maternity and Women's Hospital in Kathmandu, Nepal, from October 2 to November 21, 2014. They were randomised into two groups: 257/270 were cord clamped within 60 seconds and 209/270 after 180 seconds. Transcutaneous bilirubin was measured at discharge and 24 hours. At 4 weeks, 506 mothers were successfully contacted by phone, and the health status of the baby and their history of jaundice and treatment was recorded.

RESULTS:

Based on transcutaneous bilirubin at discharge, 22/261 (8.4%) in the early group and 25/263 (9.5%) in the delayed group (P = 0.76) were at high risk of subsequent hyperbilirubinemia. At the 4-week follow-up, jaundice was reported in 13/253 (5.1%) in the early and 17/253 (6.7%) in the delayed group (P = 0.57) and 3/253 (1.2 %) of the early and 1/253 (0.4%) of the delayed group (P = 0.62) received treatment. All analyses were based on intention-to-treat.

CONCLUSION:

Delayed cord clamping was not associated with an increased risk of hyperbilirubinaemia during the first day of life or risk of jaundice within 4 weeks compared with the early group.

KEYWORDS:

cord clamping; jaundice; neonatal hyperbilirubinaemia; newborn infant; transcutaneous bilirubin

PMID:
31240753
DOI:
10.1111/apa.14913

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