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Nutrients. 2019 Jun 24;11(6). pii: E1415. doi: 10.3390/nu11061415.

Increasing the Dose and/or Repeating Faecal Microbiota Transplantation (FMT) Increases the Response in Patients with Irritable Bowel Syndrome (IBS).

Author information

1
Section for Gastroenterology, Department of Medicine, Stord Hospital, Box 4000, 54 09 Stord, Norway. magdy.el-salhy@helse-fonna.no.
2
Department of Clinical Medicine, University of Bergen, 5007 Bergen, Norway. magdy.el-salhy@helse-fonna.no.
3
National Centre for Functional Gastrointestinal Disorders, 5021 Bergen, Norway. magdy.el-salhy@helse-fonna.no.
4
Department of Clinical Medicine, University of Bergen, 5007 Bergen, Norway. trygve.hausken@helse-bergen.no.
5
National Centre for Functional Gastrointestinal Disorders, 5021 Bergen, Norway. trygve.hausken@helse-bergen.no.
6
Department of Clinical Medicine, University of Bergen, 5007 Bergen, Norway. jan.gunnar.hatlebakk@helse-bergen.no.
7
National Centre for Functional Gastrointestinal Disorders, 5021 Bergen, Norway. jan.gunnar.hatlebakk@helse-bergen.no.

Abstract

BACKGROUND:

Faecal microbiome transplantation (FMT) appears to be an effective method for treating irritable bowel syndrome (IBS) patients. However, it is not clear if a high transplant dose and/or repeating FMT are/is needed to ensure a response. The present study was undertaken to clarify this matter.

METHODS:

Ten IBS patients who did not respond to a 30-g transplant subsequently received a 60-g transplant into the duodenum via a gastroscope. The patients provided faecal samples before and 1 month after FMT. They completed five questionnaires measuring symptoms, fatigue and quality of life at baseline and then at 2 weeks, 1 month and 3 months after FMT. The dysbiosis index (DI) was measured using the GA-map Dysbiosis Test®.

RESULTS:

Seven patients (70%) responded to the 60-g transplant, with significant clinical improvements in the abdominal symptoms, fatigue and quality of life in 57%, 80% and 67% of these patients. The 60-g transplant also reduced the DI.

CONCLUSION:

FMT is an effective treatment for IBS. A high-dose transplant and/or repeated FMT increase the response rate and the intensity of the effects of FMT.

KEYWORDS:

IBS; abdominal symptoms; dysbiosis; faecal microbiota transplantation; fatigue; quality of life

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