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Indian J Ophthalmol. 2019 Jul;67(7):1217-1219. doi: 10.4103/ijo.IJO_1800_18.

Clinicopathological and immunohistochemistry correlation in a case of Vogt-Koyanagi-Harada disease.

Author information

1
Department of Ocular Pathology, Uveitis and Neuro-Ophthalmology Services, Sri Sankaradeva Nethralaya, Guwahati, Assam, India.
2
Sri Bhagawan Mahavir Vitreoretinal Services, Sankara Nethralaya, Chennai, India.
3
Department of Uveitis and Ocular Pathology, Medical Research Foundation, Sankara Nethralaya, Chennai, India.

Abstract

Vogt-Koyanagi-Harada (VKH) disease is a systemic disorder causing bilateral panuveitis. Histopathological documentation along with molecular diagnostic evidence in VKH eye is a rarity. We present a 46-year-old woman with VKH with several ocular complications and subsequently enucleation of the right eye was done because of painful blind eye. Patient had clinical complications of VKH and some of the complications were observed in histopathology. Pathology of the case showed nongranulomatous uveitis, indicating the disease in chronic recurrent stage. Immunohistochemistry showed predominant T-cell involvement in this case. The case showed clinicopathological and immunohistochemistry correlation in a case of VKH disease.

KEYWORDS:

Choroid; Vogt-Koyanagi-Harada disease; choroidal neovascular membrane; immunohistochemistry; panuveitis

PMID:
31238472
DOI:
10.4103/ijo.IJO_1800_18
Free PMC Article

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