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Mult Scler. 2019 Jun 25:1352458519860304. doi: 10.1177/1352458519860304. [Epub ahead of print]

Multiple sclerosis relapse risk in the postoperative period: Effects of invasive surgery and anesthesia.

Author information

1
Department of Neurology, University of Michigan, Ann Arbor, MI, USA.
2
College of Engineering, University of Michigan, Ann Arbor, MI, USA.
3
Department of Statistics, University of Michigan, Ann Arbor, MI, USA.
4
The Biostatistics Center, The George Washington University, Washington DC, USA.

Abstract

BACKGROUND:

Postoperative multiple sclerosis (MS) relapses are a concern among patients and providers.

OBJECTIVE:

To determine whether MS relapse risk is higher postoperatively.

METHODS:

Data were extracted from medical records of MS patients undergoing surgery at a tertiary center (2000-2016). Conditional logistic regression estimated within-patient unadjusted and age-adjusted odds of postoperative versus preoperative relapse.

RESULTS:

Among 281 patients and 609 surgeries, 12 postoperative relapses were identified. The odds of postoperative versus preoperative relapse in unadjusted (odds ratio (OR) = 0.56, 95% confidence interval (CI) = 0.18-1.79; p = 0.33) or age-adjusted models (OR = 0.66, 95% CI = 0.20-2.16; p = 0.49) were not increased.

CONCLUSIONS:

Surgery/anesthesia exposure did not increase postoperative relapse risk. These findings require confirmation in larger studies.

KEYWORDS:

Anesthesia; logistic models; multiple sclerosis; postoperative period; preoperative period; retrospective studies

PMID:
31237825
DOI:
10.1177/1352458519860304

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