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J Clin Endocrinol Metab. 2019 Jun 25. pii: jc.2019-00576. doi: 10.1210/jc.2019-00576. [Epub ahead of print]

Association between urinary triclosan with bone mass density and osteoporosis in the US adult women, 2005-2010.

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Department of Science and Education, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, CHINA.
Department of Epidemiology and Health Statistics, Hangzhou Medical College School of Public Health, Hangzhou, CHINA.
Centre for Orthopaedic Research, Orthopedics Research Institute of Zhejiang University, Department of Orthopaedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, CHINA.
School of Public Health, Hangzhou Medical College, Hangzhou, CHINA.



Laboratory studies have demonstrated that Triclosan (TCS) could result in significant interstitial collagen accumulation and an increase in trabecular bone. However, little is known about the relationship between TCS exposure and human bone health.


We used 2005-2010 National Health and Nutrition Examination Survey data to examine the association between urinary TCS concentrations with BMD and osteoporosis in the US adult women (age ≥20 years). After inclusion and exclusion, 1,848 women were finally analyzed.


After adjustment for other covariates, we observed significant associations between tertile 3 of TCS concentration and lower BMD in regions of total femur (β=-0.016, 95% CI=-0.032, -0.000), intertrochanter (β=-0.022, 95% CI=-0.042, -0.002), and lumbar spine (β=-0.014, 95% CI=-0.029, 0.001), respectively, relative to tertile 1. Compared with women at tertile 1, those at tertile 3 were more likely to have increased osteoporosis prevalence in intertrochanter [odd ratio (OR)=2.464, 95% CI = 1.190, 5.105].


this is the first epidemiological study to investigate the association between urinary TCS concentration with BMD and osteoporosis in the US adult women. We found urinary TCS concentration was negatively associated with BMD and was positively associated with the prevalence of osteoporosis. The evidence was stronger in postmenopausal women than in premenopausal women. Future prospective studies are needed to validate the findings.


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