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Curr Drug Targets. 2019 Jun 19. doi: 10.2174/1389450120666190619121658. [Epub ahead of print]

Personalized Peptide-based vaccination for treatment of colorectal cancer: rational and progress.

Author information

1
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad. Iran.
2
Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad. Iran.
3
Department of Psychiatry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran (5) Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad. Iran.
4
Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK. (7) Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad. Iran.

Abstract

Colorectal cancer (CRC) is one of the most common cancers globally and is associated with a high rate of morbidity and mortality. A large proportion of patients with early stage CRC who undergo conventional treatments develop local recurrence or distant metastasis and in this group of advanced disease, the survival rate is low. Furthermore there is often a poor response and/or toxicity associated with chemotherapy and chemo-resistance may limit continuing conventional treatment alone. Choosing novel and targeted therapeutic approaches based on clinicopathological and molecular features of tumors in combination with conventional therapeutic approach could be used to eradicate residual micrometastasis and therefore improve patient prognosis and also be used preventively. Peptide-based vaccination therapy is one class of cancer treatment that could be used to induce tumor-specific immune responses, through the recognition of specific antigen-derived peptides in tumor cells, and this has emerged as a promising anti-cancer therapeutic strategy. The aim of this review was to summarize the main findings of recent studies in exciting field of peptide-based vaccination therapy in CRC patients as a novel therapeutic approach in treatment of CRC.

KEYWORDS:

Peptide; colorectal cancer; immunotherapy; treatment ; vaccine

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