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J Med Genet. 1987 Nov;24(11):692-5.

Fetal valproate syndrome: is there a recognisable phenotype?

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1
Kennedy Galton Centre for Clinical Genetics, Radlett, Hertfordshire.

Abstract

Four infants who were exposed to sodium valproate or valproic acid during pregnancy are described. Common facial features in the three surviving infants include epicanthic folds, a flat nasal bridge, a broad nasal base, anteverted nostrils, a shallow philtrum, and a thin upper lip with a thick lower lip. Ridging of the metopic suture, congenital heart defect, postaxial polydactyly, and hypospadias were additional features in individual cases. In agreement with previous authors, we feel that there is a distinctive 'fetal valproate' phenotype.

PMID:
3123693
PMCID:
PMC1050348
[Indexed for MEDLINE]
Free PMC Article
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