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Oral Dis. 2019 Jun 24. doi: 10.1111/odi.13149. [Epub ahead of print]

Non-syndromic cleft lip with or without palate-susceptible SNPs is associated with hyperdontia.

Kan S1,2, Zhu G1,2, Du Y1,3, Fan L1,2, Yang F1,2, Lou S1,2, Li D1,2, Ma L1,2, Pan Y1,2.

Author information

1
Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
2
Department of Orthodontics, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China.
3
Department of Oral-maxillary surgery, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China.

Abstract

BACKGROUND:

Non-syndromic supernumerary teeth (NSST) or hyperdontia may share common genetic determinants with non-syndromic cleft lip with or without palate (NSCL/P). The aim of this study was to test the associations between five genome-wide-associated NSCL/P-susceptible single nucleotide polymorphisms (SNPs) (rs2235371, rs7078160, rs8049367, rs4791774, and rs13041247) and the occurrence of NSST.

MATERIALS AND METHODS:

A total of 163 cases and 326 controls were recruited and their genomic DNA was extracted from blood samples. Five NSCL/P-susceptible SNPs (rs2235371, rs7078160, rs8049367, rs4791774, and rs13041247) were genotyped by TaqMan method. Odds ratio (OR) and 95% confidence interval (CI) were used to estimate the associations between the SNPs and the risk of NSST by PLINK software.

RESULTS:

Rs4791774 (A > G) and rs13041247 (T > C) were associated with risk of NSST (rs4791774: Padd  = 0.011, OR, 95% CI = 0.62, 0.43-0.90; rs13041247: Phomo  = 0.031, OR, 95% CI = 1.79, 1.05-3.05) and one supernumerary tooth (rs4791774: Pdom  = 0.009, OR, 95% CI = 0.56, 0.36-0.87; rs13041247: Phomo  = 0.034, OR, 95% CI = 1.82, 1.05-3.15). Rs4791774 (A > G) was also showed association with risk of upper arch supernumerary teeth only (Padd  = 0.010, OR, 95% CI = 0.60, 0.41-0.89).

CONCLUSION:

Non-syndromic cleft lip with or without palate-susceptible loci rs4791774 (A > G) and rs13041247 (T > C) were associated with the risk of supernumerary teeth.

KEYWORDS:

hyperdontia; non-syndromic cleft lip with or without cleft palate; single nucleotide polymorphisms; supernumerary teeth

PMID:
31233659
DOI:
10.1111/odi.13149

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