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J Biomater Sci Polym Ed. 2019 Jul 9:1-18. doi: 10.1080/09205063.2019.1636352. [Epub ahead of print]

Titanium - castor oil based polyurethane composite foams for bone tissue engineering.

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a Facultad de Odontología , Universidad Autónoma de Yucatán , Mérida , Yucatán , México.
b Centro de Investigación Científica de Yucatán , Mérida , Yucatán , México.
c Laboratorio Académico de Ingeniería Tisular y Medicina Traslacional, FES Iztacala , Universidad Nacional Autónoma de México , Tlalnepantla , Estado de México , México.
d Escuela Politécnica Superior , Universidad de Sevilla , Sevilla , Spain.


Polyurethanes (PU) foams with titanium particles (Ti) were prepared with castor oil (CO) and isophorone diisocyanate (IPDI) as polymeric matrix, and 1, 3 and 5 wt.% of Ti. Composites were physicochemically and mechanically characterized and their biocompatibility assessed using human dental pulp stem cells (HDPSC). PU synthesis was confirmed by FTIR, but the presence of Ti was detected by RAMAN, X-ray diffraction (peak at 2θ = 40.2°) and by EDX-mapping. Materials showed three decomposition temperatures between 300 °C and 500 °C and their decomposition were not catalyzed by Ti particles. Compressive modulus (164-846 kPa), compressive strength (12.9-116.7 kPa) and density (128-240 kg/m3) tend to increase with Ti concentration but porosity was reduced (87% to 80%). Composites' foams were fully degraded in acid and oxidative media while remained stable in distilled water. HDPSC viability on all composites was higher than 80% up to 14 days while proliferation dropped up to 60% at 21 days. Overall, these results suggest that these foams can be used as scaffolds for bone tissue regeneration.


Polyurethane foam; biodegradable foams; bone regeneration; castor oil; titanium particles

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