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Clin Infect Dis. 2019 Jun 22. pii: ciz548. doi: 10.1093/cid/ciz548. [Epub ahead of print]

A novel high sensitivity bacteriophage-based assay identifies low level M. tuberculosis bacteraemia in immunocompetent patients with active and incipient TB.

Author information

1
Department of Respiratory Sciences, NIHR Respiratory Biomedical Research Centre, University of Leicester, Leicester, United Kingdom.
2
Royal Veterinary College, Hawkshead Campus, Herts, United Kingdom.
3
School of Biosciences, University of Nottingham, Sutton Bonington Campus, Leicestershire, United Kingdom.
4
Department of Respiratory Medicine, University Hospitals of Leicester NHS Trust, Glenfield Hospital, Leicester, United Kingdom.

Abstract

Haematogenous dissemination of M. tuberculosis (Mtb) is critical to pathogenesis of progressive tuberculous infection in animal models. Using a novel phage-based blood assay, we report the first concordant evidence in well-characterised immunocompetent human cohorts, demonstrating associations of Mtb bacteraemia with progressive phenotypes of latent infection and active pulmonary TB respectively.

KEYWORDS:

bacteraemia; bacteriophage; blood; human tuberculosis

PMID:
31233122
DOI:
10.1093/cid/ciz548

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