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Eur J Pharmacol. 1987 Oct 27;142(3):431-5.

Protein kinase C mediates endotoxin and zymosan-induced prostaglandin synthesis.

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1
Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, MD 20892.

Abstract

Addition of the protein kinase C activators phorbol-12-myristate-13-acetate or 1-oleoyl-2-acetylglycerol, or endotoxin (lipopolysaccharide) or zymosan, to RAW264.7 murine macrophages markedly stimulated prostaglandin E2 synthesis. The protein kinase C inhibitor 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7) blocked prostaglandin E2 synthesis in response to all these agonists. The present results suggest that activation of protein kinase C is a step in the stimulation of arachidonic acid metabolism by agonists in macrophages.

PMID:
3123256
DOI:
10.1016/0014-2999(87)90083-5
[Indexed for MEDLINE]

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