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Clin Oral Implants Res. 2019 Aug;30(8):714-724. doi: 10.1111/clr.13496. Epub 2019 Jul 21.

The effect of supportive care in preventing peri-implant diseases and implant loss: A systematic review and meta-analysis.

Lin CY1,2, Chen Z3, Pan WL1,2, Wang HL3,4.

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Department of Periodontics, Chang Gung Memorial Hospital, Taipei, Taiwan.
Chang Gung University, Taoyuan City, Taiwan.
Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA.
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Disease, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.



To evaluate the influence of supportive treatment (SPT) during a maintenance period after implant placement on implant survival rate (SR) and incidence of peri-implant diseases.


A systemic literature search for studies published up to June 2018 was conducted by two independent reviewers using Pubmed/MEDLINE, EMBASE, and Cochrane Central databases. Clinical controlled trials (CCT) involved in SPT protocol with more than 1-year follow-up were included. Quantitative meta-analyses were carried out to analyze the risk ratio (RR) of SR, the incidence of peri-implantitis, and peri-implant mucositis between SPT and non-SPT groups. Any potential confounding factors were investigated using meta-regression.


Nine CCTs fulfilled the criteria. To evaluate the influence of SPT on SR, peri-implantitis, and peri-implant mucositis, six of nine, three of nine, and three of nine articles were included in further meta-analysis, respectively. SPT group significantly showed higher SR (RR: 1.10; p < 0.001), lower prevalence of peri-implantitis (RR: 0.25; p < 0.001) and peri-implant mucositis (RR: 0.57; p < 0.001) than the non-SPT group. Meta-regression of the selected studies failed to find an association between SR, peri-implantitis, and peri-implant mucositis and confounding factors: application of chemical agents and the frequency of SPT.


SPT can potentially improve peri-implant health in terms of SR, peri-implantitis, and peri-implant mucositis. Additionally, the correlation in recall interval and adjunctive use of chemical agents during SPT to peri-implant diseases and implant loss could not be found.


maintenance; peri-implantitis; supportive treatment; survival rate; systematic review and meta-analysis


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