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Front Neurol. 2019 May 28;10:560. doi: 10.3389/fneur.2019.00560. eCollection 2019.

Cerebrovascular Disease and Perioperative Neurologic Vulnerability: A Prospective Cohort Study.

Author information

1
Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, United States.
2
Center for Consciousness Science, University of Michigan Medical School, Ann Arbor, MI, United States.
3
Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, United States.
4
Pediatric Proteome Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Abstract

Background: Stroke is a devastating perioperative complication without effective methods for prevention or diagnosis. The objective of this study was to analyze evidence-based strategies for detecting cerebrovascular vulnerability and injury in a high-risk cohort of non-cardiac surgery patients. Methods: This was a single-center, prospective cohort study. Fifty patients undergoing non-cardiac surgery were recruited -25 with known cerebrovascular disease and 25 matched controls. Neurologic vulnerability was measured with intraoperative cerebral oximetry as the primary outcome. Perioperative neurocognitive testing and serum biomarker analysis (S-100β, neuron specific enolase, glial fibrillary acid protein, and matrix metalloproteinase-9) were measured as secondary outcomes. Results: Cerebral desaturation events (an oximetry decrease ≥20% from baseline or <50% absolute value for ≥3 min) occurred in 7/24 (29%) cerebrovascular disease patients and 2/24 (8.3%) controls (relative risk 3.5, 95% CI 0.81-15.2; P = 0.094). Cognitive function trends were similar in both groups, though overall scores (range: 1,500-7,197) were ~1 standard deviation lower in cerebrovascular patients across the entire perioperative period (-1,049 [95% CI -1,662, -436], P < 0.001). No significant serum biomarker differences were found between groups over time. One control patient experienced intraoperative hypoxic-ischemic injury, but no robust biomarker or oximetry changes were observed. Conclusions: Cerebrovascular disease patients did not demonstrate dramatic differences in cerebral oximetry, cognitive trajectory, or molecular biomarkers compared to controls. Moreover, a catastrophic hypoxic-ischemic event was neither predicted nor detected by any strategy tested. These findings support the need for novel research into cerebrovascular risk and vulnerability.

KEYWORDS:

biomarkers; cerebrovascular disease; cognitive dysfunction; hypoxia-ischemia; perioperative care; stroke

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