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Neuron. 2019 Aug 7;103(3):520-532.e5. doi: 10.1016/j.neuron.2019.05.032. Epub 2019 Jun 20.

Transforming the Choice Outcome to an Action Plan in Monkey Lateral Prefrontal Cortex: A Neural Circuit Model.

Author information

1
New York University Shanghai, Shanghai, 200122, China; NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai, 200062, China; Present address: Center for Theoretical and Computational Neuroscience and Department of Neuroscience, University of Texas at Austin, Austin, TX 78712, USA.
2
New York University Shanghai, Shanghai, 200122, China; NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai, 200062, China; Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), School of Psychology and Cognitive Science, East China Normal University, Shanghai, 200062, China. Electronic address: xinying.cai@nyu.edu.
3
Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), School of Psychology and Cognitive Science, East China Normal University, Shanghai, 200062, China; Center for Neural Science, New York University, New York, NY 10003, USA; Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Zhangjiang Laboratory, Shanghai 201210, China. Electronic address: xjwang@nyu.edu.

Abstract

In economic decisions, we make a good-based choice first, then we transform the outcome into an action to obtain the good. To elucidate the network mechanisms for such transformation, we constructed a neural circuit model consisting of modules representing choice, integration of choice with target locations, and the final action plan. We examined three scenarios regarding how the final action plan could emerge in the neural circuit and compared their implications with experimental data. Our model with heterogeneous connectivity predicts the coexistence of three types of neurons with distinct functions, confirmed by analyzing the neural activity in the lateral prefrontal cortex (LPFC) of behaving monkeys. We obtained a much more distinct classification of functional neuron types in the ventral than the dorsal region of LPFC, suggesting that the action plan is initially generated in ventral LPFC. Our model offers a biologically plausible neural circuit architecture that implements good-to-action transformation during economic choice.

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