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Biol Blood Marrow Transplant. 2019 Jun 21. pii: S1083-8791(19)30379-9. doi: 10.1016/j.bbmt.2019.06.015. [Epub ahead of print]

Current Practice in Vitamin D Management in Allogeneic Hematopoietic Stem Cell Transplantation: A Survey by the Transplant Complications Working Party of the European Society for Blood and Marrow Transplantation.

Author information

1
Anthony Nolan Research Institute, Royal Free Hospital, and University College London, London, United Kingdom. Electronic address: joseros.soto@anthonynolan.org.
2
Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom.
3
Haematology Department, Hammersmith Hospital, Imperial College Healthcare Trust, London, United Kingdom.
4
Department of Clinical Haematology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom.
5
Haematology Department, Queen Elizabeth University Hospital, Glasgow, United Kingdom.
6
Anthony Nolan Research Institute, Royal Free Hospital, and University College London, London, United Kingdom; Department of Haemato-Oncology, The Royal Marsden Hospital, Sutton, United Kingdom.
7
Photopheresis Unit, The Rotherham NHS Foundation Trust, Rotherham, United Kingdom.
8
EBMT Data Office, Paris, France.
9
Department of Clinical Haematology, University College London Hospitals NHS Foundation Trust, London, United Kingdom.
10
Anthony Nolan Research Institute, Royal Free Hospital, and University College London, London, United Kingdom.
11
Department of Haematology, Oncology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
12
Department of Haematology, University Hospital Leuven and KU Leuven, Leuven, Belgium.

Abstract

Beyond its impact on bone health, numerous studies have investigated the immune-regulatory properties of vitamin D and shown how its deficiency can affect outcomes in allogeneic hematopoietic stem cell transplantation (HSCT), particularly in acute or chronic graft-versus-host disease. This survey, carried out by the Transplant Complications Working Party of the European Society for Blood and Marrow Transplantation (EBMT), describes the current clinical practice discrepancies across the EBMT HSCT programs. We therefore recommend the development of evidence-based guidelines to standardize evaluation criteria and to harmonize the management of vitamin D deficiency in patients undergoing allogeneic HSCT.

KEYWORDS:

Hematopoietic stem cell transplantation; Post-transplant complications; Supportive care; Survey; Vitamin D

PMID:
31229642
DOI:
10.1016/j.bbmt.2019.06.015

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