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Biomed Pharmacother. 2019 Jun 19;117:108989. doi: 10.1016/j.biopha.2019.108989. [Epub ahead of print]

Antidiabetic effects of water-soluble Korean pine nut protein on type 2 diabetic mice.

Author information

1
Department of Food Science and Engineering, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Nangang District, Harbin, Heilongjiang, 150090, China. Electronic address: 86064396@qq.com.
2
Department of Food Science, Cornell University, Ithaca, NY 14853-7201, USA. Electronic address: jmr9@cornell.edu.
3
Department of Food Science and Engineering, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Nangang District, Harbin, Heilongjiang, 150090, China. Electronic address: 67300498@qq.com.
4
Department of Traditional Chinese Medicine, School of Pharmacy, Hainan Medical University, Haikou, Hainan, China. Electronic address: qjq000000@163.com.
5
Department of Food Science and Engineering, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Nangang District, Harbin, Heilongjiang, 150090, China. Electronic address: zhhua@hit.edu.cn.
6
Department of Food Science and Engineering, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Nangang District, Harbin, Heilongjiang, 150090, China. Electronic address: 448767350@qq.com.
7
Department of Food Science and Engineering, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Nangang District, Harbin, Heilongjiang, 150090, China. Electronic address: zhaoht9999@163.com.
8
Department of Food Science and Engineering, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Nangang District, Harbin, Heilongjiang, 150090, China. Electronic address: wzy219001@163.com.

Abstract

Korean pine nut protein (PNP) has a variety of biological activities, which are good for human health, but its ability to preventing diabetes has not been reported. This study evaluated the effects of water-soluble proteins of Korean pine nut obtained from a dilute alkali extract on carbohydrate metabolism of type 2 diabetic mice on a model of diabetes induced using a high fat diet combined with streptozotocin. The results showed that the hypoglycemic effect of PNP at a middle dose was the most significant, which was 38.7% lower than that of control. The extract significantly improved the oral glucose tolerance and liver indexes, increased the activity of the carbohydrate metabolism enzymes, and regulated the expression of the function of key genes for carbohydrate metabolism. It had a positive effect on both insulin resistance and glycolytic/gluconeogenesis signaling. In conclusion, PNP can regulate fasting blood glucose, improve insulin resistance, correct the glucose metabolism disorder in diabetic mice, and have a positive regulatory role. As the functional food, it has the potential to be beneficial in the treatment of type 2 diabetes mellitus as a new hypoglycemic functional food.

KEYWORDS:

Gluconeogenesis; Glycolysis; Insulin resistance; Korean pine nut protein; Type 2 diabetes mellitus

PMID:
31228801
DOI:
10.1016/j.biopha.2019.108989
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