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Biochimie. 1987 Aug;69(8):901-4.

Elongating ribosomes in vivo are refractory to erythromycin.

Author information

1
Dept. of Molecular Biology, Biomedicum, Uppsala, Sweden.

Abstract

We have studied the kinetics of erythromycin inhibition of translation in growing bacteria. In order to simplify the interpretation of our data, we have used a mutant (envA), known to have an increased permeability to several antibiotics, including erythromycin. The data clearly show that an initial stage of translation is sensitive to erythromycin, but that the elongating ribosome is insensitive to the antibiotic.

PMID:
3122850
DOI:
10.1016/0300-9084(87)90218-5
[Indexed for MEDLINE]

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